FORMULA:
Each ml contains:
Medroxyprogesterone Acetate5 mg.
Excipients q.s.ad1 ml.

INDICATIONS:
Rut postponement or interruption in canines, felines and equines.
Metrorrhagia y Nymphomania.
Preventive use: a) Postponement for a long period of rut in female dogs.
In the female dog the optimum effect is achieved with the administration of subcutaneous injection of 50 mg of Medroxyprogesterone Acetate (2 ml of Celomic Injectable) 1 or 2 months before the expected rut. It is possible to change the doses according to the size of the female dog, if provided to small animals of less than 5 kg of weight 25 to 40 mg (1 – 1 ½ ml) and to those of more than 35 kg of weight, 50 to 100 mg (2 – 4 ml).

It is important that the treatment is done before the rut is expected because after that the effect could be adverse over the endometrium. Lots of studies had demonstrated that if mentioned instructions are followed the rut can be postponed for at least 6 months in the 85 – 90% of the female dogs treated and that they could be maintained without rut by the administration of Celomic Injectable within intervals of 6 months. If therapy is repeated within intervals of 5 months the postponement of rut could be permanent in approximately the 98% of treated dogs. Nevertheless should be taken into account that some female dogs begins rut more than 2 times a year. In this cases they should be treated according their cycles, taking into account that normally each injection suspends one period of rut.
When treatment begins after giving birth the correct moment for it is 1 to 2 months before the expected rut, that in practice means from 2 to 4 weeks after weaning of puppies at the age of 8 weeks.

b) Pseudo pregnancy in female dogs.
The pseudo pregnancy is common in dogs and once it presents, it comes back each following cycle.
Although there is no evidence at the moment, it is believed that pseudo pregnancy is a consequence of hormonal disorder caused by persistence of luteum.
In the prophylactic treatment with Celomic Injectable for a long term postponement of rut it inhibits the development of follicles, the ovulation and the formation of the luteum bodies. That is the explanation of why pseudo pregnancy is in this case eliminated and the experience extracted from practice shows that in dogs that had suffered this sickness it does not show up again if rut is postponed by Celomic Injectable.

c) Postponement for long period in female cats.
The female cat is a poly-oestrus animal, not being their oestrus cycles as regular as the dog ones.
This is probably the reason why Celomic Injectable does not give, in cats, as much security as in dogs oestrus postponement.

Cats are treated in every moment during the an-oestrus or when litter are retired.
Nevertheless, with relative frequency cats begin rut a few days after giving birth, that is why in that moment the treatment should be done. The dose of Celomic Injectable in cats is of 50 mg (2 ml) administrated subcutaneous, getting by this mean the postponement of oestrus for 6 months in about the 2/3 of treated animals. Celomic Tablets could also be used for a long period postponement of rut in cats.

d) Rut postponement in mares.
For rut postponement in mares it should be administrated by subcutaneous injection of 100 to 150 mg (4 – 6 ml) of Celomic Injectable. The treatment could be initiated even when there are external manifestations of rut. In practice, the treatment is generally applied in cases of competitions or races.
It should be emphasized the fact that the mare treatment has not shown collateral adverse effects.

CURATIVE USE:
a) Metrorrhagia in female dogs and cats.
The metrorrhagia post-partum or the one due to prolonged ruts can be treated with 50 mg (1 flask of 1 ml) administrated by subcutaneous injection or with Celomic Tablets. It is generally observe a cure within 3 and 8 days after treatment.

b) Nymphomania in female cats
This condition is frequently appreciable in female cats, owed to a long period or excessive production of oestrogenic hormones by ovarian cysts. The sickness is treated administrating 50 mg (1 flask of 2 ml subcutaneous injection).

c) Satyriasis in dogs.
In cases of excessive sexual urges in dogs, depending on the dog size and its situation, generally it is recommended an initial dose of 50 to 100 mg adjusting it according to its effects and according to its effects extent the interval length between treatments.

d) Nymphomania in mares.
The recommended dose in this cases is up to 250 mg (10 ml), that controls the condition for 1 – 2 months. If a continuous effect is desirable the treatment should be repeated when symptoms come back.

DOSAGE:
Oestrus postponement:
Less than 5 Kg.:
f. dogs: 30 – 50 mg,
f. cats: 30 – 50 mg
From 5 to 25 Kg:
f. dogs: 50 mg
More than 25 Kg.:
f. dogs: 50 – 100 mg
Metrorrhagia:
f. dogs: 50 – 100 mg
f. cats: 50 mg
Nymphomania:
f. cats: 50 mg
Satyriasis:
f. cats: 50 mg
Mares: 250 mg

ANIMAL SPECIES TO WHICH IS DESTINED:
Dogs, cats and equines.

ROUTE OF ADMINISTRATION:
Injectable, subcutaneous.

PRECAUTIONS:
The prophylactic treatment with Celomic should only be applied on animals completely healthy. It is not
advisable to treat animals sexually immature because the effect of hormones in this stage of the animal
can perturb its normal development.